Mutations of NOTCH 1 , FBXW 7 , and prognosis in T - lineage acute lymphoblastic leukemia

| 1338 | haematologica | 2009; 94(10) et al. in the current issue represents a significant step forward in this chain as it links biology to prognosis by showing that lower risk non-del(5q) MDS patients with RPS14 haplo-insufficiency tend to have a prolonged survival. Be that as it may, the fact remains that defective ribosomal biogenesis, a previously unsuspected mechanism, is emerging as a surprise contender for the lead role in disrupting erythropoiesis in a variety of anemias. An entirely original subject of research has exploded on the MDS scene, one which links congenital and acquired anemias, and which is likely to produce exciting biological insights in the future, especially when combined with the emerging improved technology.